Clinical studies have shown that after 30 days of using ProBiora3, S. oralis and S. uberis bacteria have permeated beneath the gum line and become established in the periodontal pocket.

Conversely, if harmful, disease-causing bacteria are allowed to colonize in the periodontal pocket, the result is advanced periodontal disease. To address this, it is increasingly more common as well as very painful to have dentists clean teeth below the gum line. Research has revealed that even after the aggressive process of scaling to clean out the periodontal pockets, the future oral health of the patient is determined by the type of bacteria that colonizes first in the base of that clean pocket. If the bad bacteria are first to colonize, the disease condition will quickly return. If the good bacteria are first, then good oral health will be established and the dental office procedure will have been successful (Socransky and Hafajee, 1992, J. Perio, p. 322).

ProBiora3 can provide a deep impact by rebalancing the oral flora in a simple, painless, non-invasive daily routine. No other product impacts oral health below the gum line to get to the root of the problem.

In clinical trials, twice-daily administration of S. rattus JH145^TM, S. oralis KJ3^TM  and S. uberis KJ2^TM as combined in ProBiora3 substantially affected the levels of both dental and periodontal pathogens in the mouth. The studies found that simply by using ProBiora3, the levels of periodontal pathogens were reduced in plaque samples taken from below the gum line, at the bottom of the periodontal pocket. Existing mouthwashes and toothpastes that typically contain an antibacterial agent are able to only affect those areas of the mouth that the rinse is able to directly contact, which limits their effectiveness to contact with plaque above the gum line. Furthermore, the antibacterial agent is quickly washed from the mouth while the ProBiora3 bacteria have high substantivity; i.e., they have a prolonged duration of contact with disease-susceptible surfaces in the mouth and thus a prolonged beneficial activity.

Oral-care products and foods developed using this probiotic approach can safely maintain and promote oral health by normalizing the balance of the indigenous flora in favor of microorganisms associated with both healthy teeth and periodontal or gum tissues.