ProBiora3 is the first complete oral care probiotic blend that supports tooth and gum health, freshens breath and whitens teeth. ProBiora3 is the result of 25 years of study on the delicate balance of oral microflora and the disruption of that balance by lifestyle, stress, medications and diet. After one month of using ProBiora3, the natural oral microflora balance is greatly restored. This healthy balance will continue to provide benefits that will grow over time.

In the ProBiora3 formulation, the S. rattus strain does not produce lactic acid and competes for space on the surface of the teeth as well as for nutrients against the indigenous strains of S. mutans. With daily use, a growing population of good bacteria builds and wins out over the harmful bacteria for space and nutrients. The other two bacteria (S. oralis and S. uberis) in Probiora3 compete with the organisms that impact gum health by colonizing in same places they prefer. Not only do S. oralis and S. uberis compete for the same spaces, they also produce hydrogen peroxide, to effectively dominate the organisms that effect gum health. The colonies of good bacteria suppress the level of disease-causing organisms. Good health depends upon a certain balance of oral micro flora. Opportunistic (harmful) bacteria are always present, but in bad health they have taken the opportunity to replicate excessively and maintain an imbalance from health by actively suppressing the beneficial bacteria.

A formulation containing ProBiora3 bacteria in lyophilized form will become activated upon contact with saliva.

Yes, healthy mouths typically contain significant numbers of S. oralis and S. uberis. The particular strain of S. rattus used in ProBiora3 was isolated from a human mouth, but S. rattus strains are present in only certain population groups and are not wide spread. Furthermore, S. rattus strains typically produce lactic acid, while the strain used in ProBiora3 has naturally evolved to not produce lactic acid. This is what makes our specific strain so unique among human S. rattus isolates quite rare.

ProBiora3 is made from natural organisms found in healthy mouths, which creates complete safety. ProBiora3 does not overload the mouth with bacteria that are not normal residents. ProBiora3 delivers benefits that get to the root of the problem and do not simply provide a peripheral effect in the mouth.

Because of the current emphasis on fast results, traditional whitening products contain excessively high concentrations of hydrogen peroxide, which can damage gums and cause pitting and etching of the enamel of the teeth. High doses of peroxide also cause tooth sensitivity. Standard whitening products roughen the surface of veneers and dental crowns and can damage the porcelain materials due to their high concentration of peroxide. As a result, people with dentures, false teeth, bridges, veneers or dental crowns are advised not to use conventional whitening products. The naturally occurring low level of peroxide that results from using ProBiora3 is safe and effective for use on all of types of restorative treatments including dental crowns, veneers and dentures, and will not etch or pit those restorative dental materials. ProBiora3 is an ideal product for use with all types of dental restorations and those with dental braces.

Domestic and international patents have been filed and the status is currently Patent Pending.

ProBiora3 is not a short-term or one-time fix, since there is a constant battle against opportunistic bacteria; these good bacteria set up base of operations like an army that starts to colonize and restore the balance of oral microflora. For best results, ProBiora3 is used twice daily.

The ProBiora3 probiotics are tolerant when exposed to high or low food and beverage temperatures; otherwise if you drank hot coffee or ate ice cream you would be able to kill the other resident bacteria in the mouth.

ProBiora3 is a local-acting probiotic with effectiveness confined to the mouth; the natural habitat of these bacteria is the mouth, so they provide no benefit and cause no harm as they travel though the digestive system. The bacteria do not survive in nature outside of the mouth and so simply pass through the gastro-intestinal tract and are excreted. They are not absorbed into the body, nor do they stimulate an immune response. The action is restricted to the tooth surface and the gum tissue.

In clinical trials, young, healthy individuals, using ProBiora3 twice daily for a month, experienced a significant drop in the numbers of opportunistic bacteria in their mouths. In weeks, users will begin to notice whitening and an improvement in breath.

The time-frame for effective flora balance is approximately one month, with consistent daily use.

Yellowing, surface discoloration and staining are the result of lifestyle choices: tobacco use, coffee, tea, beets, etc. Anything that stains affects the color of the teeth. Teeth are porous and have lots of tiny cracks that hold stains. When traditional whiteners are used, the level of hydrogen peroxide is so high that it creates a roughness on the surface of the tooth, as well as irritation of the gum tissue. This roughness increases the amount of film that builds up on the tooth and the micro cracks that hold stains. This is not the same as discoloration from within the tooth (dentin) caused by early life demineralization and exposure to such drug agents as tetracycline. ProBiora3 produces a low level hydrogen peroxide as a natural by-product. This natural mechanism enables the gradual whitening effect and stain removal from the teeth without any of the side effects of commercial whiteners.

Fast-acting conventional whiteners using high concentrations of hydrogen peroxide with shortened contact times can cause tooth sensitivity and transient gum inflammation. This high concentration of hydrogen peroxide and other chemicals is hard on teeth and can create pitting (rough surface textures) and etching, making otherwise healthy teeth more prone to staining. ProBiora3 naturally produces low-levels of hydrogen peroxide that create continual contact with the teeth, whitening without sensitivity or gum irritation. ProBiora3 is the only complete oral care probiotics delivering 24 hour a day, 7 days a week coverage for balancing and brightening.

Using Probiora3 and continuing to consume teeth-staining foods is similar to having a piece of chalk (foods and beverages with staining potential) in one hand and an eraser (ProBiora3) in the other. ProBiora3 probiotic bacteria will colonize on the tooth surface and the low-level natural by-product of hydrogen peroxide will be in constant contact with the teeth. The whitening and stain-removal process will continue naturally, on a 24/7 basis.

Anyone looking for an over-the-counter option for maintaining oral health is well suited for ProBiora3. This novel formulation is designed to restore oral balance on tooth and gingival surfaces and can be used beneficially by all ages. There are no identified sub-populations that can not use ProBiora3, though those with advanced periodontal disease should seek professional treatment first. ProBiora3 is safe for use during pregnancy and there are no known contraindications.

The probiotics used in ProBiora3 are freeze dried and do not require refrigeration. Proper formulation and packaging can insure a shelf life of about 18 months for products containing ProBiora3. The viability and thus shelf life of probiotics products containg ProBiora3 are determined by the excess amount of colony forming units (CFU) included during manufacturing necessary to ensure the labeled CFU minimum at the end of the marketed expiration date.

No, prebiotics are not required. Prebiotics typically are used to support the growth of probiotics in the gut. In the oral cavity, the probiotic strains used in ProBiora3 are not dependent on prebiotics as a source of soluble fiber/nutrients since there is typically a ready supply of fermentable carbohydrates in the mouth. Since ProBiora3 is delivered right into the mouth, prebiotics are not necessary.

No. These strains are naturally occurring and were all isolated from healthy mouths.